Cenac was born in New York City, and attended high school in Texas at the Jesuit College Preparatory School of Dallas. He attended university at the University of North Carolina at Chapel Hill before moving to Los Angeles to further his career.
Having worked for three years as a writer and story editor on King of the Hill and may have appeared in Episode 9 Season 11 as a guard, Cenac garnered public attention in a The Doomed Planet comedy sketch impression of then-senator-, and future president-, Barack Obama discussing possible campaign posters. He was considered for a role on sketch show Saturday Night Live in which he would have portrayed the Democratic presidential candidate, but was passed over in favor of Fred Armisen.
In June 2008, Cenac was hired as a correspondent and writer on The Daily Show with Jon Stewart. After making several comedic appearances along with other correspondents, Cenac filed his first field report on July 21, 2008, concerning Democratic Presidential nominee Barack Obama. He continues to integrate satirical Black-oriented material in his Daily Show segments, including "Rapper or Republican". In October 2009, he worked with rapper Slim Thug on the music video "Still a Boss", a parody of how the recession is affecting the rap community. Cenac appeared in the lead role in the indie movie Medicine for Melancholy, a race-relations drama released in 2008.
- ": Wyatt Cenac Biography". The Daily Show. 2010. Retrieved 11 June 2010.
- PRNewswire (21 September 2009). "Comedy Central Wins Three Big Primetime Emmy Awards for Long-Time Favorites 'The Daily Show' and 'South Park". Reuters. Retrieved 11 June 2010.
- Robert Wilonsky (Wednesday, 25 June 2008). "Tonight on The Daily Show, Jesuit Grad Wyatt Cenac Becomes Part of "The Best F*&#ing News Team Ever"". The Dallas Observer - Unfair Park. Retrieved 11 June 2010. Check date values in:
- Wyatt Cenac; David Guy Levy. (29 January 2007) (.swf). Barack Obama: Campaign Posters. [video]. The Doomed Planet. http://thedoomedplanet.com/view.cfm?id=33&format=youTube. Retrieved 11 June 2010.
- Wyatt Cenac; Jeremy Ring. (Monday, 21 July 2008) (video). Baruch Obama. [.swf]. Comedy Central The Daily Show. http://www.comedycentral.com/videos/index.jhtml?videoId=177061. Retrieved 11 June 2010.
- Wyatt Cenac; Jon Stewart; Jason Jones. (Tuesday July 29, 2008) (video). Rapper or Republican. [.swf]. Comedy Central The Daily Show. http://www.comedycentral.com/videos/index.jhtml?videoId=178008. Retrieved 11 June 2010.
- Pam Grady (2007). "Medicine for Melancholy". San Francisco International Film Festival. Retrieved 11 June 2010.
- "Full cast and crew for Fanboy and Chum Chum (2009)". The Internet Movie Database. 2010. Retrieved 11 June 2010.
- Template:Title without disambig at the Internet Movie Database
- Wyatt Cenac official website
- Medicine for Melancholy podcast with Wyatt Cenac at GreenCine Daily